eu.orgPR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. There are a number of different methods to administer the Lysine. EZH1 mediates methylation on histone H3 lysine 27 and enhances EZH2 in maintaining stem cell id and executing pluripotency. PR-Set7-mediated monomethylation of histone H4 lysine 20 at specific genomic areas induces transcriptional repression.

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